Conducting well-designed structured studies are important when formulating any vaccine. For live viral vaccines, some specific challenges include limited analytical tools and inherent variability that make evaluation difficult. While most viral vaccines are a liquid presentation, the product may not necessarily be stored in liquid form, but can include frozen, lyophilised or even spray dried. When properly formulated and stabilised, a product should retain potency and efficacy for years if stored appropriately.
Recently, I presented at the Bioprocessing Summit talking about designed approaches that provide a firm foundation for sound formulation of live vaccines.